Cervical spondylosis
Conditions
Interventions
Group 1:denosumab
Group 2:placebo
Sponsors
The First Affiliated Hospital of Southern University of Science and Technology (Shenzhen People's Hospital)
Eligibility
Sex/Gender
All
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patients aged 40 to 90 years with radiculopathy or cervical myelopathy presented with radiculopathy, clumsy hands, gait disorders, hyperreflexia, Babinski's sign, bladder dysfunction, ankle clonus, and 2 or more horizontal spinal cord compression, as confirmed by MRI or CT at the C3-C7 vertebral level.
Exclusion criteria
Exclusion criteria: Cervical C2-C7 kyphosis greater than 5 degrees (measured by standing cervical lateral radiographs), segmental kyphosis, structurally significant ossification of the posterior longitudinal ligament, prior cervical spine surgery, or other health-related conditions (nervous system).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| osteocalcin in the N terminal molecular fragment;n-terminal propeptide P1NP of procollagen type 1;c-terminal crosslinking type 1 collagen terminal peptide CTx;serum total calcium;parathyroid hormone;total phosphorus;total alkaline phosphatase;albumin;Dual - energy X-ray examination of lumbar spine bone mineral density;hip bone mineral density;Bone marrow edema and adjacent intervertebral disc were detected by MRI;Cervical curvature;The operation section;Anti-osteoporosis drugs;Duration of symptoms;cobb angle;Nonsteroidal pain medication use;Numeric Rating Scale;Visual Analog Scale;the modified Japanese Orthopaedic Association;Neck Disability Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality-adjusted life years;EuroQol- 5 Dimension; | — |
Countries
China
Contacts
Public ContactWang Hongyu
The First Affiliated Hospital of Southern University of Science and Technology (Shenzhen People's Hospital)
Outcome results
None listed