rheumatoid arthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Aged between 18-65 years, meeting the ACR and EULAR 2009 diagnostic criteria for RA.
Exclusion criteria
Exclusion criteria: 1. Currently participating in or participating in other clinical studies for the treatment of RA within 1 month before this study; 2. Women who are planning to give birth in the near future, or are pregnant or breastfeeding; 3. Combined with serious cardiovascular, lung, liver, kidney, hematopoietic system and other diseases; 4. Overlap other rheumatic diseases such as systemic lupus erythematosus, Sj?gren's syndrome, severe knee osteoarthritis, etc.; 5. Combined with severe extra-articular manifestations such as persistent high fever, interstitial pneumonia, renal amyloidosis, constrictive pericarditis, central nervous system vasculitis, etc., glucocorticoid treatment is required; 6. With active gastrointestinal disease, or peptic ulcer within 30 days prior to the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| disease activity score of 28 joints (DAS28); | — |
Secondary
| Measure | Time frame |
|---|---|
| joints morning stiffness score;joints swelling index;joints tenderness index;the Short-Form McGill Pain Questionnaire(SF-MPQ).;erythrocyte sedimentation rate (ESR);C reactive protein (CRP);Rheumatoid factor (RF);interleukin-1ß(IL-1ß);interleukin-6(IL-6);tumor necrosis factor-a(TNF-a);interleukin-18(IL-18);matrix metalloproteinase 3 (MMP-3); | — |
Countries
China
Contacts
Hospital (T.C.M.) Affiliated to Southwest Medical University