Pulmonary function recovered after pneumonectomy
Conditions
Interventions
Experimental group1:Esticketamine 0.5mg/kg +0.5mg/kg.h continuous infusion
Experimental group2:Esticketamine 1mg/kg +0.5mg/kg.h continuous infusion
control group:No
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged > 18 years old; 2. ASA I-III grade; 3. Plan to undergo thoracoscopic pneumonectomy (metastatic tumor resection, segmentectomy, lobectomy, pneumonectomy or pleuropneumonectomy); 4. Informed consent, willing to accept follow-up.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to related active ingredients or excipients; 2. Those with serious risk of elevated blood pressure or intracranial pressure; 3. Patients with poorly controlled or untreated hypertension (resting systolic/diastolic blood pressure over 180/100 mmhg); 4. Untreated or insufficiently treated hyperthyroidism; 5. Severe cardiopulmonary disease and liver and kidney dysfunction; 6. Those with a history of mental illness and drug abuse; 7. Impaired verbal communication, unable to express correctly; 8. Refuse to participate in research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxygenation index;Alveolar arterial oxygen partial pressure difference;Compliance of the lung;Incidence of pulmonary complications three days after operation;Postoperative NRS pain score;Adverse reactions associated with esketamine; | — |
Countries
China
Contacts
Public ContactGao Jin
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed