Study on the Predictive Model Construction and the neural and inflammatory mechanisms of acupuncture in WMH with Depression

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100051509

Enrollment

Unknown

Registered

2021-09-25

Start date

2021-10-01

Completion date

Unknown

Last updated

2022-06-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depression

Interventions

Experimental group:acupuncture

Control group:no

Health control (no randomization):No

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Test group: 1. Aged 40 to 70 years; 2. Meet the diagnostic criteria for WMH and depression; 3. The total score of the 17 items of the Hamilton Depression Scale (HAMD-17) is greater than 7 points, less than or equal to 17 points, and the self-rating depression scale score (SDS) is greater than or equal to 50 points; 4. Middle school education level or above, can cooperate with the completion of the neuropsychological scale evaluation; 5. Voluntarily sign the informed consent. Control group: 1. Aged 40 to 70 years; 2. Meet the diagnostic criteria of WMH; 3. The total score of the 17 items of the Hamilton Depression Scale (HAMD-17) is less than or equal to 7, and the Self-rating Depression Scale (SDS) score is less than 50; 4. Middle school education level or above, can cooperate with the completion of the neuropsychological scale evaluation; 5. Voluntarily sign the informed consent. Healthy group: 1. Aged 40 to 70 years; 2. Middle school education level or above, can cooperate with the completion of the neuropsychological scale evaluation; 3. Voluntarily sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Suffering from other serious neurological diseases, such as large-area cerebral infarction, cerebral hemorrhage, traumatic brain injury, brain tumor, intracranial infection, epilepsy, metabolic encephalopathy, white matter lesions induced by non-vascular factors, etc.; 2. Have a history of alcohol or other drug dependence or abuse, or a severe mental disorder, and a history of psychotropic drug use within the past 1 month; 3. There is obvious cognitive impairment (MMSE<=24 points), language or motor dysfunction; 4. Suffering from severe systemic diseases or insufficiency of vital organs; 5. Women who are breastfeeding or pregnant; 6. There are contraindications to MRI examination, metal in the body, claustrophobia, etc.

Design outcomes

Primary

Measure	Time frame
Inflammatory cytokines;functional Magnetic Resonance Imaging;	—

Countries

China

Contacts

Public ContactCui Fangyuan

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

konglonger@126.com+86 13811660716

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026