alopecia areata
Conditions
Interventions
control group:minoxidil solution treatment of treatment of alopecia areata
experimental group:ablative fractional CO2 laser treatment of alopecia areata
Sponsors
Dermatology Hospital of Southern Medical University
Eligibility
Sex/Gender
Male
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Chinese mild-to-moderate alopecia areata patients aged 18 to 65 years(stable period), the current duration of scalp hair loss is at least 6 months, and the longest is not more than 5 years; there is no evidence of natural final hair regeneration within the past 3 months ; 2. According to the Salt score: 5%-49% of patients with scalp area involvement; 3. Agree to follow the experimental treatment plan and visit plan, join the group voluntarily, and sign the informed consent in writing; 4. Willing to use the same shampoo throughout the test and keep the same hairstyle, color and length.
Exclusion criteria
Exclusion criteria: 1. Medical history/surgical history of any uncontrollable serious or clinical system disease that may affect the treatment and effectiveness evaluation, such as circulatory system, nervous system, blood system, immune system, mental system disease, etc.; 2. Hair loss caused by other reasons, including but not limited to syphilitic alopecia, androgenetic alopecia (AGA), scarring alopecia, traction alopecia, alopecia in growth period or malnutrition of thyroid disease, hair loss caused by chemotherapy/radiotherapy, etc. caused hair loss; 3. Patients with scalp skin diseases that affect the evaluation of efficacy, scalp trauma or other scalp skin lesions requiring topical drug treatment, such as fungal or bacterial infection, severe seborrheic dermatitis, scalp psoriasis, contact dermatitis, severe folliculitis or scalp atrophy, etc.; 4. Combining diseases that affect hair growth, such as: connective tissue disease, inflammatory bowel disease, moderate to severe anemia (hemoglobin level =10 kg within 3 months) )Wait; 5. Those who have a history of hair transplantation or need to wear wigs for a long time during the trial treatment; 6. Those who have used topical medicines for hair loss within 3 months before screening; 7. Received scalp radiation and/or laser or surgical therapy within 12 months prior to screening; 8. Those who use shampoo or conditioner with hair growth effect within 1 month before screening For example, Fengtian, Bawang, Fulv Deya, Head & Shoulders Scalp X shampoo, etc.); 9. Patients who plan to use any other adjuvant therapy or concomitant therapy in addition to the treatment of this trial to treat hair loss during the study; 10. Have a history of malignant tumor; 11. The patient has uncontrolled hypertension (blood pressure higher than 140 mmHg/90 mmHg), or a history of hypotension (blood pressure lower than 90 mmHg/60 mmHg); 12. Any one or more of the results of Treponema pallidum antibody or human immunodeficiency virus (HIV) antibody or hepatitis B surface antigen or hepatitis C virus antibody are positive; 13. Have undergone major surgery within 3 months before screening, or plan to undergo major surgery during the trial; 14. Those who have participated in or are participating in clinical trials of other interventional drugs or medical devices within 3 months before screening; 15. The researcher believes that the subjects have other conditions that may affect compliance or are not suitable to participate in this study; 16. Those who have a history of drug abuse, drug addiction or alcohol dependence before screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Target Area Hair Counts; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hair growth situation;Target Area Hair width; | — |
Countries
China
Contacts
Public ContactLiu Zhenfeng
Dermatology Hospital of Southern Medical University
Outcome results
None listed