hyperbilirubinemia of newborn
Conditions
Interventions
Experimental group:Using ETCOc to identify the risk of hemolytic conditions, and combined to TCB to establish the threshold of phototherapy.
control group:Empirical assessment of hemolysis by pediatricians, and using TCB to establish the threshold of phototherapy.
Sponsors
Guangzhou Women and Children's Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Newborns with gestational age >= 35 weeks and birth weight >=2000 grams; 2. TCB over 40 percentile was monitored within 72 hours after birth (according to Bhutani neonatal hour-bilirubin histogram); 3. Obtain informed parental consent.
Exclusion criteria
Exclusion criteria: 1.Hospitalized newborns who need respiratory support after birth (including oxygen therapy and ventilation); 2.The presence of severe or life-threatening congenital malformations (cardiovascular malformations, pulmonary malformations, chromosomal abnormalities); 3.The presence of nasal mucosa injury, posterior nostril atresia and Pilot sequence signs; 4.The mother has a history of smoking or passive smoking in the last trimester of pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of phototherapy within 7 day after birth; | — |
Secondary
| Measure | Time frame |
|---|---|
| postnatal hours when requiring phototherapy within 7 days after birth;TcB,TSB,ETCOc levels of the participants when requiring phototherapy within 7 days after birth;Maternal-fetal ABO incompatibility, ABO HDN or G6PD diagnoses the incidence of hemolytic disease; | — |
Countries
China
Contacts
Public ContactYuan Yuan
Guangzhou Women and Children's Medical Center
Outcome results
None listed