Chronic Periodontitis
Conditions
Interventions
Normal saline control group:Immediately after the basic periodontal treatment is completed, a bilateral multi-point injection of 0.6ml of normal saline is performed on a single tooth of the patient
Stem Cell Therapy Group:Immediately after the completion of basic periodontal treatment, bilateral multi-point injections were given to a single tooth of the subject, and the treatment dose was 1×10^7
Stem cell secondary administration group:Immediately after basic periodontal treatment is completed, the subject will be given bilateral multi-point injections to a single tooth. The treatment dose is
Sponsors
Beijing Stomatological Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-65 years; (2) Volunteer to participate in this clinical study and sign the "Informed Consent"; (3) Radiological examination of periodontal defect site showed wedge-shaped bone defect; (4) The probing depth (PD) of the periodontal defect site is 4-8mm.
Exclusion criteria
Exclusion criteria: (1) Blood pressure of subjects with hypertension within 1 month before surgery: systolic blood pressure >= 180mmHg or diastolic blood pressure >= 110mmHg; (2) Patients with systemic system diseases (malignant tumor subjects or those with positive tumor tests during the screening process, diabetes subjects, heart disease causing heart failure, myocardial infarction within six months; angina symptoms within six months; congenital heart sick.); (3) Those who have used non-steroidal anti-inflammatory drugs, steroid (steroid) hormone therapy, and/or long-term use of hormones, and those who have used bisphosphonates within 3 months before surgery; (4) Systemic infection; (5) Those who have received surgical treatment at the site of periodontal defect and adjacent periodontal tissue; (6) Those who are known to be allergic to any materials used during surgery; (allergic, have a history of allergies to blood products;) (7) Patients with severe periodontal disease (alveolar bone resorption exceeds two-thirds of the root length); (8) Patients with severe liver and kidney dysfunction; (9) People with bleeding tendency or coagulation dysfunction (WBC count WBC 10 cigarettes/day); (15) Those whose expected survival period is less than 12 months; (16) Other situations where the researcher thinks it is inappropriate to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Periodontal attachment level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the height of the periodontal defect;Change in average density of alveolar ridge;Periodontal probing depth;Exploratory bleeding index; | — |
Countries
China
Contacts
Public ContactYi Liu
Beijing Stomatological Hospital, Capital Medical University
Outcome results
None listed