Allogeneic hematopoietic stem cell transplantation
Conditions
Interventions
1:splenic radiotherapy
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing haploidentical stem cell transplantation; 2. Aged 18 to 60 years old; 3. ECOG score 0-1; 4. Those who have been screened positive of HLA-I or II antibodies before transplantation (MFI value >10000); 5. The informed consent forms are signed voluntarily by the subjects participated in this study.
Exclusion criteria
Exclusion criteria: 1. Patients combined with other progressing malignant diseases; 2. Patients combined with serious and uncontrolled infections or serious chronic diseases and was accessed not fit for chemotherapy; 3. Heart failure: Ejection fraction (EF) =2 mg/dl, AST> 2.5 ULN, serum creatinine (SCr)> 2.5 mg/dl; 5. Patients who Refuse to be involved in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MFI of HLA antibody sites: <4000;Rate of successful implantation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of engraftment of platelet;Time of engraftment of neutrophil;Overall survival of 3 years; | — |
Countries
China
Contacts
Public ContactDepei Wu
The First Affiliated Hospital of Soochow University
Outcome results
None listed