Sepsis
Conditions
Interventions
Experimental group:Rimazzolam
Control group1:Dexmedetomidine group
Control group2:Disoprofol
Control group3:midazolam
Sponsors
The Third Hostipital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years; 2. Patients who meet the criteria for sepsis requiring invasive mechanical ventilation for at least 24 hours; 3. Treat sepsis and mechanical ventilation.
Exclusion criteria
Exclusion criteria: 1. The presence of severe chronic liver disease (Child-Pugh grade B or C); 2. Patients with chronic renal failure; 3. Patients with neurological diseases; 4. Patients with drug dependence, alcohol dependence, mental system diseases and cognitive impairment; 5. Pregnant women or patients allergic to remazolam; 6. Patients with severe myocardial infarction or heart failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mechanical ventilation time;length of Intensive Care Unit stay;The airway peak pressure (daily maximum);Mean airway pressure (daily maximum);respiratory rate (daily maximum);Daily occurrence of man-machine incoordination times;PaO2/FiO2 (worst daily oxygenation index);Diaphragm thickness at the end of breath;Diaphragm thickness at the end of inhalation;Diaphragm motion amplitude;Richmond AgitationSedation Scale;acute physiology and chronic health evaluation scoring system score;Critical-Care Pain Observation Tool score;electroencephalography bispectral index;Continuous electroencephalography monitoring;muscle activity score;Sequential Organ Failure Score;White blood cell count;procalcitonin;IL-1;IL-6;IL-10;TNF-a;central venous pressure;Cardiac ejection fraction;blood flow velocity integral;cardiac output;Left ventricular end-diastolic volume;Left ventricular end-systolic volume;inferior vena cava width; | — |
Countries
China
Contacts
Public ContactFang Mingxing
The Third Hostipital of Hebei Medical University
Outcome results
None listed