Sleep Disorder
Conditions
Interventions
Control group:infusion of 0.025 ml/kg/h saline
Experimental group:infusion of 0.3µg/kg/h dexmedetomidine
Sponsors
Fudan University Eye Ear Nose and Throat Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists classification (ASA classification) 1-2; 2. Laryngectomy under general anesthesia; 3. Patients admitted to the ICU before 20:00 pm.
Exclusion criteria
Exclusion criteria: 1. A history of schizophrenia, epilepsy or Parkinson's disease; 2. History of sleep disorders (hypnotics/sedatives taken within the last month); 3. History of obstructive sleep apnea syndrome; 4. Preoperative sick sinus syndrome, severe sinus bradycardia (heart rate less than 50 beats/min) or atrioventricular block level two or above but no pacemaker; 5. Preoperative coma; 6. Brain injury or neurosurgery; 7. Severe liver dysfunction (Child-Pugh class C); 8. Severe renal insufficiency (preoperative dialysis); 9. Mechanically ventilated patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| percentage of N1 sleep;percentage of N2 sleep;percentage of N3 sleep;percentage of rapid eye movement sleep; | — |
Secondary
| Measure | Time frame |
|---|---|
| Richmond AgitationSedation Scale score;The Confusion Assessment Method delirium score;Pain Numerical Rating Scale ; | — |
Countries
China
Contacts
Public ContactShen Xia
Fudan University Eye Ear Nose and Throat Hospital
Outcome results
None listed