breast cancer
Conditions
Interventions
Group 1:PEG-rhG-CSF was injected 4 hours after chemotherapy
Group 2:PEG-rhG-CSF was injected 48 hours after chemotherapy
Sponsors
The Seventh Affiliated Hospital, Sun Yat-sen University (Shenzhen)
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 65 years; 2.Breast cancer diagnosed by pathological histology or cytology; 3.Determine the patient's chemotherapy regimen and dose according to the latest CSCO guidelines for breast cancer treatment; 4.Patients who plan to complete their chemotherapy program at the same center; 5.ANC >= 1.5*10^9/L before chemotherapy; Platelets >= 80*10^9/L; Hemoglobin >= 100g/L; No significant abnormalities in liver and kidney function; 6.Understand the content of the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Have an infection that is difficult to control or have received antibiotics within 72h prior to chemotherapy; 2.Patients with abnormal bone marrow hyperplasia and other abnormal hematopoietic functions; 3.Received a bone marrow or hematopoietic stem cell transplant within the previous 3 months; 4.During pregnancy or lactation; 5.There are obvious signs of blood system diseases and serious complications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of neutropenic fever; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of chemotherapeutic dose adjustment and chemotherapy delay due to neutropenia during each cycle of chemotherapy;Salvage RHG-CSF utilization rate;Antibiotic utilization rate;The cost of each cycle of chemotherapy; | — |
Countries
China
Contacts
Public ContactLei Kefeng
The Seventh Affiliated Hospital, Sun Yat-sen University (Shenzhen)
Outcome results
None listed