PFA type ependymoma
Conditions
Interventions
Experimental group:Targeted drug therapy
Control group:Conventional therapy
Sponsors
The Children's Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1.Children with PFA ependymoma (H3K27me3 (-)) of posterior fossa confirmed by postoperative pathological diagnosis in tertiary A hospitals in China must be enrolled, aged 0 to 18 years; 2.Diagnostic images (preoperative and postoperative) must be included in the clinical experimental database of PFA ependymoma in the Neurosurgery Department of Fudan University Pediatric Hospital for evaluation; 3.The enrolled children and their guardians could understand and accept follow-up; 4.At the time of enrollment evaluation, the children should be satisfied that they have been 1 month or more after surgery, their vital signs and general conditions are stable, conscious, and have self-swallowing function.
Exclusion criteria
Exclusion criteria: 1.Children with unstable vital signs, endotracheal intubation, dysphagia and involuntary consciousness should be excluded from the experimental group; 2.There is no evidence of recurrence or metastasis 5 years after surgery; 3.Clinically, children with serious systemic diseases unrelated to tumor (such as severe infection, severe failure of cardiovascular system, respiratory system, liver or other organs) cannot safely take targeted drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-Free Survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival;Partial response rate; | — |
Countries
China
Contacts
Public ContactLi Hao
The Children's Hospital of Fudan University
Outcome results
None listed