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Comparative dose-response study of hyperbaric ropivacaine for spinal anesthesia for cesarean delivery in preterm singleton versus twin pregnancies

Comparative dose-response study of hyperbaric ropivacaine for spinal anesthesia for cesarean delivery in preterm singleton versus twin pregnancies

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100051382
Enrollment
Unknown
Registered
2021-09-22
Start date
2021-10-01
Completion date
Unknown
Last updated
2024-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm single and twin elective cesarean section

Interventions

singleton group 1:10mg hyperbaric ropivacaine for spinal anesthesia
singleton group 2:12mg hyperbaric ropivacaine for spinal anesthesia
singleton group 3:14mg hyperbaric ropivacaine for spinal anesthesia
singleton group 4:16mg hyperbaric ropivacaine for spinal anesthesia
singleton group 5:18mg hyperbaric ropivacaine for spinal anesthesia
twins group 1:10mg hyperbaric ropivacaine for spinal anesthesia
twins group 2:12mg hyperbaric ropivacaine for spinal anesthesia
twins group 3:14mg hyperbaric ropivacaine for spinal anesthesia
twins group 4:16mg hyperbaric ropivacaine for spinal anesthesia
twins group 5:18mg hyperbaric ropivacaine for spinal anesthesia

Sponsors

Women's Hospital School of Medicine, Zhejiang University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1.Inclusion criteria of group S: (1)American College of Anesthesiologists (ASA) grade II; (2)Gestational weeks =150cm; (4)Weight=150cm; (5)Weight<=110kg.

Exclusion criteria

Exclusion criteria: 1.Patients refuse to participate in the study; 2.Labor into the active phase; 3.Allergy to amide local anesthetics; 4.Parturients with severe heart disease.

Design outcomes

Primary

MeasureTime frame
Successful rate of spinal anesthesia;

Secondary

MeasureTime frame
Sensory plane block;Motor block;Pain score;Maternal noninvasive blood pressure, heart rate, and oxygen saturation;Operation condition;Maternal vital signs;Umbilical Arterial Blood Gas Analysis;Total placental weight;Total Birth Weight of Newborns;Neonatal Apgar Score;Adverse reactions such as hypotension;

Countries

China

Contacts

Public ContactQian Xiaowei

Women's Hospital School of Medicine, Zhejiang University

qianxw@zju.edu.cn+86 15700157161

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026