lung caner
Conditions
Interventions
Control group:Simple general anesthesia and postoperative intravenous analgesia
Experimental group:Thoracic paravertebral nerve block - general combined anesthesia and postoperative continuous paravertebral analgesia
Sponsors
The First Medical Center, Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged>=65 years; 2.Patients undergoing thoracoscopic lobectomy or partial lobectomy under general anesthesia; 3.The patient agrees to participate in the clinical study and signs the informed consent.
Exclusion criteria
Exclusion criteria: 1.Emergency surgery; 2.ASA physical status classification>=IV,BMI<=18kg/m^2 ?BMI<=30kg/m^2; 3.Patients with a history of preoperative chronic pain or abuse of psychotropic and narcotic drugs; 4.Patients with contraindications to paravertebral block anesthesia, including local infection or rash at the puncture site, long-term anticoagulant therapy or severe coagulation abnormalities; 5.Patients with sick sinus syndrome, severe sinus bradycardia (HR< 50 beats/min), or second-degree or above atrioventricular block without pacemaker; 6.Hypotension (SBP < 90mmHg, MAP < 70mmHg or SBP decreased by more than 30% from base) or expected survival < 24h; 7.Patients enrolled in other drug trials within the last 6 months; 8.Patients judged to lack the capacity for informed consent; 9.Other reasons that are considered unsuitable for study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sleep quality on postoperative night;1 year postoperative survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| pain scores;Postoperative recovery quality scale;the incidence of postoperative delirium;postoperative pulmonary complications;other postoperative complications and 30-day mortality;requirement of opioid;the sleep quality and depression/anxiety state after 1,3,12 months;incidence of postoperative chronic pain; | — |
Countries
China
Contacts
Public ContactFu Qiang
Chinese PLA General Hospital
Outcome results
None listed