Ventricular Premature Complexes
Conditions
Interventions
Sponsors
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of Western medicine for premature ventricular contractions; the frequency of premature ventricular contractions is classified as Myerburg grade 3-4 and the morphology is classified as A-D; patients with premature ventricular contractions with 500 beats/24h<=premature beats<=10000 beats/24h; 2. Patients with premature ventricular contractions of yin and yang deficiency type based on TCM syndrome differentiation; 3. Aged 18-75 years old; 4. Have not participated in other drug clinical trials before being selected; 5. Voluntarily participate in this clinical study and sign the informed consent form, insist on taking the medicine for 4 weeks, and complete the pre-treatment and post-treatment questionnaires, blood tests, and follow-up work with fixed contact information.
Exclusion criteria
Exclusion criteria: 1. Combined with bradyarrhythmia (<50 beats/min) including sick sinus syndrome and atrioventricular block (second or third degree atrioventricular block); 2. Sustained ventricular tachycardia, non-sustained ventricular tachycardia and persistent atrial fibrillation; 3. Serious illness requiring other antiarrhythmic drugs or associated with other serious illnesses; 4. Arrhythmias caused by drugs, electrolyte disturbances, acid-base balance disorders, emotions and other factors; 5. Patients with unstable angina pectoris, myocardial infarction and various cardiomyopathy of coronary heart disease; uncontrolled hypertension, such as grade 3 hypertension or higher risk, or severe hypotension; uncontrolled diabetic patients; liver and kidney In functional tests, alanine aminotransferase or aspartate aminotransferase exceeds 1.5 times the upper limit of the normal reference value, urea nitrogen exceeds 1.2 times the upper limit of the normal reference value, and serum creatinine exceeds the upper limit of the normal reference value; severe respiratory dysfunction or asthma Patients with primary hematopoietic system diseases, other system diseases (such as hyperthyroidism, etc.), poor peripheral circulation perfusion, severe peripheral vascular disease and premature ventricular contractions of unknown etiology; 6. Allergic, mentally ill, heavy drinker, smoker; 7. Pregnant or lactating women; 8. Those who are taking beta-blockers or have contraindications to beta-blockers; 9. Those who have participated in other clinical trials in the past 3 months or those who are considered inappropriate by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of premature ventricular beats;Tpeak-end interval;Tpeak-end dispersion;QT dispersion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total heart rate;Maximum heart rate;Minimum heart rate;Average heart rate;Blood routine;Hepatic function test;Renal function test;Generalized Anxiety Disorder-7 (GAD-7);Patient Health Questionnaire-9 (PHQ-9);Self-Rating Depression Scale (SDS);Self-Rating Anxiety Scale(SAS);TCM Symptom Scale; | — |
Countries
China
Contacts
Public ContactHe Qingyong
Guang'anmen Hospital China Academy of Chinese Medical Sciences
Outcome results
None listed