pre-eclampsia
Conditions
Interventions
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Confirmed pregnancy; 2. Pregnancy time = 24 kg/m2.
Exclusion criteria
Exclusion criteria: 1. Aged < 18 years; 2. Severe vomiting during pregnancy; 3. Bleeding diseases; 4. Peptic ulcer; 5. Allergic to aspirin and metformin; 6. Long-term use of non-steroidal anti-inflammatory drugs before enrollment; 7. Contraindications of metformin and aspirin and other serious diseases, including but not limited to: renal dysfunction caused by heart failure (shock), acute myocardial infarction and sepsis; congestive heart failure and other serious heart and lung diseases requiring drug treatment Severe infection and trauma, major surgical operation, clinical hypotension and hypoxia, etc. 4 weeks before screening; acute or chronic metabolic acidosis, including diabetic ketoacidosis and diabetic ketoacidosis with or without coma Insulin treatment is required; 4 weeks before screening, those who received intravascular injection of iodinated contrast agent; 8. Participated in another concurrent experiment within 28 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of preeclampsia in Chinese overweight pregnancies; | — |
Secondary
| Measure | Time frame |
|---|---|
| Placental growth factor (PLGF)/soluble fms-like tyrosine kinase-1 (sFlt-1) ratio);Maternal outcomes;Offspring outcomes; | — |
Countries
China
Contacts
Public ContactWei Yuan
Peking University Third Hospital
Outcome results
None listed