sepsis
Conditions
Interventions
Group 1:Physiological saline CRRT adjuvant therapy
Group 2:Ozonated Water CRRT adjuvant therapy
Sponsors
Shanghai Oriental Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years, male or female; 2. The diagnostic criteria for sepsis in the new 2016 SSC guidelines were: infection-induced organ dysfunction, increased SOFA score (Table 2-1) by >= 2 points at baseline, and SOFA baseline of 0 points for patients without underlying organ dysfunction; the diagnostic criteria for septic (septic) shock were: on the basis of a definite diagnosis of sepsis, with persistent hypotension, and on the basis of adequate blood volume supplementation, vasopressors were still required to maintain mean arterial pressure >= 65 mmHg and serum lactate level > 2 mmol/L (18 mg/dL). 3. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Massive blood loss, acute bleeding, anemia (Hb= 20mg/day; 11. The investigators assess that the subjects are unable or unwilling to comply with the requirements of the research protocol. 12. Acute alcoholism. 13. Severe water and electrolyte disturbances; 14. Hemochromatosis, patients receiving copper or iron therapy; 15. Allergy to anticoagulants (sodium citrate).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-reactive protein;TNF-a; | — |
Countries
China
Contacts
Public ContactLiao Lijun
Shanghai Oriental Hospital
Outcome results
None listed