Vascular depression
Conditions
Interventions
Combined therapy group :Escitalopram 10 mg once daily, and 5 mg of Tandospirone Citrate three times per day in Week 1
from Week 2, Tandospirone Citrate was increased to 10 mg per time and administered three times per day.
Monotherapy group:Escitalopram 10 mg once daily.
Sponsors
Fujian Medical University Union Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Diagnosis according to the diagnosis standard for the first or repeated episodes of depression in the Diagnostic and Statistical Manual of Mental Disorders Edition IV (DSM-IV) issued by the American Psychiatric Association. 2.Diagnosis according to the diagnosis standard for vascular depression recommended by Alexopoulos. 3.Score over 17 points in Hamilton Depression Rating Scale (HAMD). 4.Score of 14 points or more in Hamilton Anxiety Scale (HAMA). 5.Score between 17 and 26 points (exclusive) in Montreal Cognitive Assessment (MoCA). 6.A clear mind and self-care ability, and capability of answering almost all scales independently.
Exclusion criteria
Exclusion criteria: 1. Current psychological diseases other than depression and anxiety. 2. Other nerve system diseases such as epilepsy, Alzheimer's disease, Parkinson's disease and intracranial tumor. 3. Severe or unstable physical diseases such as heart, liver, kidney, endocrine, blood and respiratory diseases. 4. Allergy to Escitalopram or Tandospirone Citrate. 5. High suicide risk, with a score over 30 points in the Suicide Assessment Scale (SUAS). 6. Proven alcohol or drug dependence, with a score of 5 points or more in the Michigan Alcoholism Screening Test (MAST). 7. Poor medication adherence, with a score of less than 6 points in the Morisky Medication Adherence Scale-8 (MMAS-8). 8. Inability to undergo head MRI scan. 9. Severe visual or hearing impairment or severe aphasia or limb dysfunction that might affect examinations. 10. Participation in other clinical studies in the past 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale(HAMD);Hamilton Anxiety Scale (HAMA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Rey Auditory Verbal Learning Test (RAVLT);Verbal Fluency Test (VFT);Trail Making Test (TMT);Digital Span Test (DST);Clock Draw Test (CDT);Clinical Global Impression (CGI); | — |
Countries
China
Contacts
Public ContactYingchun Xiao
Fujian Medical University Union Hospital
Outcome results
None listed