lower limb surgery
Conditions
Interventions
Sufentanil combined with esketamine group:Sufentanil combined with esketamine for analgesia after operation
Sufentanil group :Sufentanil for analgesia after operation
Sponsors
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ASA I-III level; 2. Aged 45-80 years; 3. BMI <= 35kg/m2; 4. It is planned to undergo elective lower extremity surgery; 5. Combined spinal-epidural anesthesia is planned; 6. The patient voluntarily provides postoperative analgesia and the patient or authorizer signs the informed consent; 7. New York Heart Association (NYHA) cardiac function class I-II; 8. Patients should fast for at least 2 hours before surgery; fast for at least 6-8 hours; 9. There are no factors of difficulty in ventilation and intubation.
Exclusion criteria
Exclusion criteria: 1. Language communication barriers, no self-control operation ability; 2. Suffering from mental or neurological diseases; 3. Contraindications for spinal anesthesia, including patients who refuse spinal anesthesia, coagulation disorders (PT/APTT higher than the upper limit of the reference value), etc.; 4. Taking sedatives and analgesics, long-term use and abuse of psychotropic drugs, or drug addiction in the past 1 week; 5. Allergic to the subject drug; 6. Patients with severe risk of elevated blood pressure or intracranial pressure; 7. Patients with poorly controlled hypertension (arterial hypertension, resting systolic/diastolic blood pressure 180/100mmHg); 8. Pulmonary diseases such as airway obstruction, asthma, and known difficult airways.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total dosage of sufentanil in PCIA 48h after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS scores of subjects at 6h, 12h, 18h, 24h, 48h after operation;Total dosage of esketamine in PCIA 48h after operation;Effective compressions and total number of compressions;Seek to use other pain medications;Adverse reactions after surgery;Evaluate overall patient satisfaction; | — |
Countries
China
Contacts
Public ContactHan Lin
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Outcome results
None listed