Chronic obstructive pulmonary disease,Obstructive sleep apnea, Overlap syndrome
Conditions
Interventions
Non-invasive ventilation therapy+ usual care group:Non-invasive ventilation therapy + conventional therapy
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 95 Years
Inclusion criteria
Inclusion criteria: We enrolled severely ill patients whose medical providers gave indications for use of long-term NIV therapy at home due to refractory hypercapnia or repeated relapse of respiratory failure despite adequate pharmacotherapy.
Exclusion criteria
Exclusion criteria: 1. Low risk of OSA as determined by the Berlin questionnaire; 2. Previous positive airway pressure therapy in patients with obstructive sleep apnea (OSA) or chronic obstructive pulmonary disease (COPD); 3. Neuromuscular or chest wall disease; 4. Clinical indications for invasive mechanical ventilation; 5. End-stage chronic disease, i.e. New York Heart Association stage IV heart failure, advanced cancer and renal failure on dialysis; 6. Cognitive impairment or acute psychotic episode.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| re-hospitalization;Pulmonary artery pressure; | — |
Countries
China
Contacts
Public ContactXie Jiang
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed