Pelvic tumors
Conditions
Interventions
Conventional anesthesia + conventional analgesia group:Hydromorphone analgesic pump was used after anesthesia according to the routine pelvic tumor anesthesia in department of Anesthesiology, Peking U
Conventional anesthesia + lidocaine analgesia group:According to the routine pelvic tumor surgery anesthesia in department of Anesthesiology, Peking University People's Hospital, hydromorphone analges
Lidocaine anesthesia + conventional analgesia group:Continuous infusion of lidocaine during operation and postoperative hydromorphone analgesic pump
Lidocaine anesthesia + Lidocaine analgesia group:Lidocaine was continuously pumped intraoperatively, hydromorphone analgesic pump was used postoperatively and lidocaine analgesic pump was also used
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged more than 18 years and less than 65 years; 2. ASA I-III; 3. Accept pelvic tumor surgery; 4. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant women; 2. Emergency surgery; 3. Adults protected by law (under judicial protection, guardianship or supervision), persons deprived of their liberty; 4. Atrioventricular block, sinoatrial node block or intraventricular block; 5. Sinus bradycardia (basal heart rate less than 55 beats/min); 6. Preoperative hypotension (systolic blood pressure less than 90mmHg); 7. Preoperative otolithiasis, Meniere's syndrome, vertebral artery stenosis; 8. Cerebrovascular disease; 9. NSAIDs drug contraindications; 10. Allergic to anesthetics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Opioid dosage 72 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cost of central vascular complications (sinus bradylosis, sinus tachycardia, atrial fibrillation, ventricular fibrillation, myocardial infarction, cardiac arrest, etc.);the amount of sufentanil and remifentanil used during surgery;what happens during surgery (blood pressure, heart rate, PI, ANI, body temperature, BIS);Cost of vasoactive drugs (ephedrine, norepinephrine, atropine, nicardipine, esmolol, etc.) during surgery;the amount of transfusion, blood loss and urine during surgery;Co-operative complications (hypoxemia, allergy, intraoperative awareness, etc.);The time between withdrawal of medicine and removal of endotracheal intubation;Plugs into Aldrete at a cost of more than 9 minutes;pain in active and resting state at 2h, 4h, 6h, 24h, 48h and 72h after endotracheal intubation (NRS score was adopted);At 24h and 48h after surgery, the dose of opioids was used and The Times of analgesic pump pressure;Incidence of opioid-related adverse reactions (hypoxemia, nausea and vomiting, postoperative intestinal obstruction) after surgery.;The incidence rate of cardiovascular complications (atrial fibrillation, ventricular fibrillation, conduction block, myocardial infarction, heart failure, cardiac arrest) after radiotherapy;Postoperative first exhaust time, defecation time;The results of C-reactive protein and esR before and on the third day after surgery and before discharge;postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactZhang Ran
Peking University People's Hospital
Outcome results
None listed