type 2 diabetes mellitus combined with nonalcoholic fatty liver disease
Conditions
Interventions
control group:Conventional western medicine treatment
Sponsors
Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. All patients meet the diagnostic criteria of TCM and Western medicine for type 2 diabetes and non-alcoholic fatty liver disease, and HbA1c <= 10%; 2. Aged between 20-75 years; 3. Liver function is basically normal: AST or ALT < 2.5 times the upper limit of normal, and total bilirubin is normal; 4. The experimental group did not take traditional Chinese medicine for diabetes and non-alcoholic fatty liver at least 2 weeks before enrollment; the control group did not use hypoglycemic drugs and drugs for the treatment of non-alcoholic fatty liver at least 3 days before enrollment; excluded drugs Metabolic effects. 5. All experimental personnel voluntarily participated in this clinical study, signed the informed consent, and had good compliance.
Exclusion criteria
Exclusion criteria: 1. Those who cannot conduct experiments in accordance with the research procedures, including patients with chronic diseases such as cardiovascular and cerebrovascular diseases and mental diseases; 2. Patients treated with insulin; 3. Patients with disease changes that make it difficult to evaluate the effectiveness and safety of the intervention, such as those with severe hepatic and renal insufficiency; 4. Allergic constitution or those who have discomfort symptoms or a history of drug allergy after taking drugs; 5. Pregnant and lactating women; 6. Patients who have participated in other clinical studies in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum lipids;fasting blood sugar;2h postprandial blood glucose;glycosylated hemoglobin;untargeted metabolomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| TCM syndrome score;visceral fat;Fatty liver grade and disease activity index score; | — |
Countries
China
Contacts
Public ContactPiao Chunli
Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine
Outcome results
None listed