Breast cancer
Conditions
Interventions
Control group:0.9%NS intravenously
0.3mg/kg esketamine group:0.3 mg/kg esketamine after induction of anesthesia
0.5mg/kg esketamine group:0.5 mg/kg esketamine after induction of anesthesia
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Breast cancer patients who were diagnosed with breast cancer by mammography, puncture examination and breast color Doppler ultrasound and underwent radical mastectomy; 2. Aged between 18-60 years; 3. ASA: I-II grade; 4. No sleep disorder before surgery; 5. Those who signed the informed consent and were willing to be followed up.
Exclusion criteria
Exclusion criteria: 1. Patients with obvious abnormal heart, lung, liver and kidney functions and abnormal blood coagulation function before surgery; 2. Hypertensive patients who are difficult to control with drugs (resting blood pressure exceeds 180/100mmHg); 3. Patients with a history of glaucoma; patients with severe risk of increased intracranial pressure; 4. Patients with language comprehension disorder, mental illness, etc. who cannot cooperate; 5. Those who have taken antidepressants or sedatives for a long time in the past (valium, tricyclic antidepressants, etc.); 6. Untreated or insufficiently treated patients with hyperthyroidism; 7. Patients with contraindications to esketamine (arteriosclerosis, coronary heart disease, cardiac insufficiency, pulmonary heart disease, pulmonary hypertension); 8. The patients themselves or their family members refuse to participate in the trial or sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Recovery Assessment Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| First post-operative exhaust and defecation time;Ricker Sedation Agitation Score;Analgesic and emetic relief times;Total hospital stay; | — |
Countries
China
Contacts
Public ContactChen Xiuxia
Outcome results
None listed