Postoperative Cognitive Dysfunction (POCD)
Conditions
Interventions
Gold Standard:Cognitive function scale - Mini-Mental State Examination (MMSE)
Montreal Cognitive Assessment Scale MoCA-B
Mini-Mental State Assessment Scale (Mini-Cog).
and 
 
serum 
S100-ß 
protein
neuron-specific 
enolase
sAßPPa
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective internal fixation of lower extremity fractures, knee arthroplasty, and hip arthroplasty; 2. American Society of Anesthesiologists (ASA) grade I-II, aged 65 years and above, and conscious during the perioperative period.
Exclusion criteria
Exclusion criteria: 1. Suffering from central nervous system and psychological diseases, long-term use of sedatives and antidepressants in the past year; 2. Parkinson's disease; 3. Severe hearing or visual impairment; 4. Drug dependence; 5. Alcoholism; 6. Those who cannot communicate with doctors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal flora and metabolite SCFA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum S100-beta protein;Neuron-specific enolase; | — |
Countries
China
Contacts
Public ContactBi Jiangjiang
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed