Effects of antidepressants on intestinal microflora and metabolites in patients with depression

Correlation study of intestinal microflora and metabolites with antidepressant effect in patients with depression

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100051157

Enrollment

Unknown

Registered

2021-09-15

Start date

2021-10-08

Completion date

Unknown

Last updated

2022-05-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

major depressive disorder (MDD)

Interventions

depression group:antidepressive therapy

control group:none

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-65 years; 2. Meet the MDD diagnostic criteria of DSM-5; 3. Hamilton Depression Rating Scale (HAMD-24) total score >= 20 points.

Exclusion criteria

Exclusion criteria: 1. Other mental disorders (such as bipolar disorder, schizophrenia or schizoaffective disorder); 2. Serious physical disease (such as tumor, heart disease, organic brain disease, liver disease, kidney disease); 3. Acute or chronic infection, allergy or autoimmune disease; 4. Antibiotics, corticosteroids or anti-inflammatory drugs have been used in the past 6 weeks; 5. Patients during pregnancy or puerperium; 6. Diagnosis of psychoactive substance abuse/dependence, including alcohol, tobacco or drugs; 7. Received antidepressant or antipsychotic medication within the past 4 weeks.

Design outcomes

Primary

Measure	Time frame
gut microbiota;metabolites;	—

Countries

China

Contacts

Public ContactYuan Yonggui

Zhongda Hospital Affiliated to Southeast University

2426028137@qq.com+86 25 83285120

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026