autism spectrum disorder (ASD)
Conditions
Interventions
Normal control group:None
High-dose vitamin D in the ASD+GDD+ group:Rehabilitation training + vitamin D3 300 units/Kg.d, the maximum does not exceed 5000 units/day
Low-dose vitamin D for ASD+GDD+ group:Rehabilitation+vitamin D3 1000 U/d
Sponsors
The First Affiliated Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
2 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. Normal control group: (1) Healthy children aged 2 to 6 years with normal development level. (2) The guardian agrees to participate in this study and signs the informed consent. 2. GDD/ID group: (1) Compliant with DSM-5 GDD or ID diagnosis. (2) Aged between 2 years and 6 years. (3) The guardian agrees to participate in this study and signs the informed consent. 3. ASD+GDD+ group: (1) Conform to the diagnosis of DSM-5 ASD with GDD. (2) Aged between 2 years and 6 years. (3) The guardian agrees to participate in this study and signs the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who have been treated with vitamin D within the past 1 month. 2. Those with elevated blood calcium. 3. Patients with chronic diseases of the nervous, respiratory, digestive, urinary, cardiovascular and other systems. 4. Those who have a history of febrile convulsion, craniocerebral injury, intracranial infection and other neurological diseases in the past. 5. Those with abnormal head imaging in the past. 6. There are contraindications for head MRI examination. 7. The patient or the patient's guardian refuses to evaluate and discontinue treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 25-hydroxyvitamin D;Autism Behavior Checklist, ABC;Childhood Autism Rating Scale, CARS; | — |
Secondary
| Measure | Time frame |
|---|---|
| the Chinese version of the Griffifiths Mental Development Scales, GMDS;Autism Treatment Assessment Form;Infant-Junior High School Student Social Living Ability Scale;Clinical Response Overall Rating Scale;Magnetic resonance spectroscopy;Magnetic resonance diffusion-weighted imaging;Diffusion tensor imaging;Diffusion kurtosis imaging;Functional MRI;Thin layer MRI scan of head;Intestinal flora detection;Whole genome sequencing; | — |
Countries
China
Contacts
Public ContactJia Feiyong
The First Affiliated Hospital of Jilin University
Outcome results
None listed