Difficult airway
Conditions
Interventions
Control group:Dexmedetomidine combined with sufentanil
Experimental group:Dexmedetomidine combined with esketamine hydrochloride
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Select elective patients undergoing general anesthesia surgery with awake nasotracheal intubation under fiberoptic bronchoscopy; Preoperative airway assessment: Modified Mallampati grade III or IV; 2. The American Society of Anesthesiologists' preoperative patient classification (ASA classification) is grade I-II; 3. Aged 18-75 years, gender is not limited; 4. Body mass index 18-32kg/m^2 (BMI=weight (kg)/height^2 (m^2)); 5. Understand and agree to participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with central nervous system or mental illness; 2. Difficulty in language communication, unable to cooperate with the research; 3. Abnormal coagulation function and bleeding tendency; 4. Those who are allergic to esketamine or dexmedetomidine; 5. Those who have participated in or are participating in other clinical trials within 4 weeks before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intubation score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulse oximetry;Pulse oximetry;Heart rate;Blood pressure;Respiratory rate;Bispectral index;Ramsay sedation score; | — |
Countries
China
Contacts
Public ContactYou Wenjing
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed