Total hip arthroplasty
Conditions
Interventions
Group B:Blank control
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients who need primary unilateral THA surgery due to severe osteoarthritis of the hip; 2. Age is 18~75 years old; 3. The preoperative American Society of Anesthesiologists (ASA) classification (anesthesia risk assessment) was grade I-III.
Exclusion criteria
Exclusion criteria: 1. Patients with heart, lung and other important organ failure; 2. Abnormal liver and kidney function (ALT, AST> 1.5 times the normal value, blood BUN> -8.3 mmol/L, blood Scr> 115 umol/L); 3. Diabetic patients with poor control of blood sugar levels, who are judged by the researchers to be at risk of infection; 4. Combined with disturbance of consciousness or mental illness; 5. Have a history of hip open surgery; 6. Neuromuscular dysfunction affects lower extremity function; 7. Patients with severe coagulation disorders; 8. Combined with severe medical or surgical diseases or weak constitution, unable to tolerate surgery; 9. Severe osteoporosis, metabolic bone disease, radiation bone disease, and tumor around the hip joint; 10. Active infection foci in the body (systemic or local infection lesions); 11. Clearly diagnosed mental diseases and endocrine system diseases; 12. Users of hormone drugs and immunosuppressants; 13. Women in family planning, lactation and pregnancy during the entire clinical research period; 14. Those who have participated in other clinical trials within 3 months; 15. The investigator believes that it is not suitable to participate in this clinical trial due to other reasons; 16. Those who are allergic to or have contraindications to the drugs used in this study; 17. History of alcoholism, opioid addiction; 18. Language barriers and those who cannot complete the scale assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood stress index;Hamilton Anxiety Scale, HAMA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale, HAMD;Central Sensitivity Questionnaire;Postoperative morphine consumption;Harris hip score;Pittsburgh sleep quality index,PSQI;quality of life scale;range of motion;VAS score;Length of stay; | — |
Countries
China
Contacts
Public ContactKang Pengde
West China Hospital of Sichuan University
Outcome results
None listed