Colorectal Cancer
Conditions
Interventions
Ketamine group (group K):5 minutes before the start of surgery, 0.3 mg/kg of ketamine was intravenously injected
Control group (group C):5 minutes before the start of surgery, 0.006 ml/kg of saline was intravenously injected
Sponsors
Beijing Ditan Hospital of Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients undergoing laparoscopic radical resection of colorectal cancer, male or female, aged 34 ~ 65 years, body mass index 18 ~ 25 kg/m2, ASA grade I or II, the expected operation time is less than 6h, the expected blood loss is less than 800ml.
Exclusion criteria
Exclusion criteria: 1. Patients with poor comprehension ability, mental disorders or central nervous system disorders before surgery and can not cooperate; 2. Patients with diabetes or heart disease; 3. Intraoperative use of hormone therapy; 4. Patients allergic to ketamine or opioids; 5. Patients with severe liver or kidney dysfunction; 6. Alcohol addiction or often taking sedative and analgesic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Christensen postoperative fatigue score; | — |
Secondary
| Measure | Time frame |
|---|---|
| TNF-a;IL-6;S100ß protein;Neuron-specific enolase;;identity consequence fatigue scale; | — |
Countries
China
Contacts
Public ContactCheng Hao
Department of Anesthesiology, Beijing Ditan Hospital of Capital Medical University
Outcome results
None listed