Knee Osteoarthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for knee osteoarthritis of the American College of Rheumatology; 2. At least moderate or less pain in the knee joint on most days in the past month (Pain Numerical Scale, VAS score <7); 3. Age 40-75 years old (including 40 and 75 years old); 4. Subjects should stop taking painkillers, and only allow them to take related drugs when the pain is unbearable, such as analgesics or non-steroidal anti-inflammatory drugs. But the subjects cannot take hormone drugs; 5. Willing to sign the informed consent. 6. Patients who meet the above 5 items at the same time can be included in this study.
Exclusion criteria
Exclusion criteria: 1. Those who have received hormone therapy within the past 3 months; 2. Received intra-articular hyaluronidase injection within the past 6 months; 3. Received joint irrigation or arthroscopy within the past 1 year; 4. Diseases that hinder the safe participation of the experimental design and affect the completion of the study, such as myocardial infarction or stroke, congestive heart failure, severe chronic obstructive pulmonary disease, cancer, diabetes and other serious systemic diseases in the past 3 months and serious mental illness; 5. History or clinical manifestations of bleeding tendency constitution, including current use of anticoagulants; 6. Inflammatory arthritis (such as rheumatoid or psoriasis type), the subjects will be tested for rheumatoid factor, erythrocyte sedimentation rate, and anti-O before inclusion in this trial to rule out the possibility of rheumatoid arthritis; 7. Participate in other research at the same time; 8. Those who have had knee replacement surgery; 9. Participated in the related treatment of knee osteoarthritis trials in the past; 10. Those who are too afraid of needles and knives; 11. At the same time, topical external therapy is used, such as topical sticking therapy, etc.; 12. Inability to complete various scales; 13. Unwillingness to be randomized.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| interleukin-1, interleukin-17, tumor necrosis factor, serum osteoprotegerin, osteocalcin, calcitonin; | — |
Countries
China
Contacts
Jiangsu Provincial Cadre's Sanatorium