Childhood HSCT
Conditions
Interventions
group A:PEG-RHG-CSF group was given on day 6 after transplantation, 100ug/kg (Max. 6mg)
group B:rhG-csf group was subcutaneously injected 5ug/kg/d (maximum 300ug/d) on day 6 after umbilical cord blood transplantation
Sponsors
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged 1-18 years, no gender limitation; 2. Patients with leukemia, lymphoma or solid tumors who received their first umbilical cord blood hematopoietic stem cell transplantation; 2. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cardiac insufficiency and cardiac ejection fraction EF less than 60%; Or severe arrhythmias; 2. With severe pulmonary insufficiency (obstructive or restrictive ventilatory disorder); 3. With severe liver function impairment, liver function indexes (ALT, TBIL) were more than 3 times higher than the upper limit of normal value (ULN). 4. With severe renal insufficiency, the renal function index (Cr) was more than 2 times higher than the upper normal value (ULN). 5. Or Cr of 24 hours urinary creatinine clearance was lower than 50ml/min; 6. Severe active infection before transplantation; Infections that are difficult to control after transplantation; 7. Have a history of allergy or intolerance to domestic pegylated recombinant human granulocyte stimulating factor; The investigator evaluated other reasons for ineligibility.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neutrophil recovery time; | — |
Secondary
| Measure | Time frame |
|---|---|
| side effects; | — |
Countries
China
Contacts
Public ContactXu Honggui
Sun Yat-Sen Memorial Hosipital
Outcome results
None listed