The relationship between plaque features and multimodal MRI features in the brain of patients with carotid artery stenosis and cognitive impairment and cognitive impairment

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100051043

Enrollment

Unknown

Registered

2021-09-10

Start date

2023-03-27

Completion date

Unknown

Last updated

2023-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carotid artery stenosis

Interventions

Carotid artery stenosis group:NA

Healthy control group:NA

Eligibility

Sex/Gender

All

Age

35 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 35-75 years; 2. Han population; 3. Right-handed; 4. Previous carotid ultrasound, CTA or MRI imaging tests clearly showed that the carotid artery did not have any stenosis; or have not had the above tests; 5. Good cognitive function, no mental or psychological diseases; 6. Understand and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with carotid artery stenosis who have undergone carotid endarterectomy or carotid artery stenting; 2. Previous or current head MRI examination found that there were exact infarction foci, softening foci, deformity or white matter hyperintensity Fazekas grade 3 in the skull; (Small infarction lesions can be included: non-basal ganglia lesions in the cerebral hemisphere < 10 mm in length, basal ganglia lesions < 3 mm in length, brainstem lesions with a length diameter < 5 mm); 3. Past/combined cognitive-related neuropsychiatric disorders: ischemic or hemorrhagic stroke, Alzheimer's disease, Parkinson's disease, ischemic hypoxic encephalopathy (cardiac arrest, carbon monoxide poisoning), epilepsy, hydrocephalus, intracranial infection or trauma, psychiatric and psychological diseases; 4. Past/combined cognitively related endocrine or metabolic diseases: thyroid dysfunction, long-term diarrhea or malnutrition; 5. Combined with major physical diseases, such as severe cardiovascular disease, liver and kidney dysfunction; 6. Pain combined, unable to cooperate with MRI examination or MRI contraindications; 7. Previous history of severe allergies or gadolinium contrast allergy; 8. there are any other factors in the study that are not suitable for inclusion or affect participants' participation/completion of the study; 9. The investigator deems it inappropriate to participate in the study.

Design outcomes

Primary

Measure	Time frame
Plaque typing;Gray matter volume;Function Connectivity;	—

Secondary

Measure	Time frame
Carotid artery lumen stenosis degree (rate);Wall load;Plaque composition (property);Blood vessel length;Cerebral cortex thickness;Cerebral cortex surface area;Cortical groove;Folding curvature;	—

Countries

China

Contacts

Public ContactXia Chao

West China Hospital, Sichuan University

692185040@qq.com+86 13880721279

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026