Sepsis
Conditions
Interventions
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years; 2. Actual weight >= 45kg; 3. ICU hospitalization time is expected to be >= 72 hours; 4. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Neurosurgery in the last three months; 2. Ischemic stroke occurred within the last 3 months; 3. Intracranial hemorrhage occurred within the last 3 months; 4. Systolic blood pressure >= 180mm Hg, diastolic blood pressure >= 110mm Hg, or vasoactive drug infusion is required for more than 12 hours; 5. Heavy bleeding in the past week, treat; 6. Abnormal coagulation at screening: INR>=2 times the upper limit of normal, or APTT>=2 times the normal value; 7. Thrombocytopenia at screening: platelet count <=75x10^9/L8; 8. Other heparin contraindications (such as heparin-induced thrombocytopenia, pregnancy, lactation); 9. Ultrasonography of lower extremities cannot be performed (such as bilateral amputations above the knees or severe distal lower extremity burns); 10. Limited life support, life expectancy <= 14 days, or palliative care; 11. Contamination (for example, 3 times of low molecular weight heparin was used after being admitted to the ICU); 12. Contraindications to blood products.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bedside ultrasound screening;Bleeding and coagulation time;D dimer, procalcitonin, thromboregulatory protein, thrombin/antithrombin complex, tissue-type plasminogen activator - activator inhibitor 1 reactivator, plasminase/antiplasminase A2 complex, antithrombin III;Incidence of proximal deep venous thrombosis of the lower leg; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay in ICU;Mechanical ventilation time;The incidence of MODS;28?90-day survival curve;28 - day mortality;Incidence of pulmonary embolism;Expenses during ICU hospitalization;All - cause mortality in hospital;Thrombolysis diagram(TEG); | — |
Countries
China
Contacts
Public ContactKang Yan
West China Hospital of Sichuan University
Outcome results
None listed