Repeated implantation failure
Conditions
Interventions
experimental group:Preimplantation genetic testing for aneuploidy
control group:histologic examination only
Sponsors
Chongqing Maternal and Child Health Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 38 Years
Inclusion criteria
Inclusion criteria: 1. Meet the indications for IVF or ICSI; 2. The history of embryo transfer failures in the past >= 2 times, and the cumulative transfer of at least 4 transferable cleavage embryos or 2 transferable blastocysts; 3. Female age =1 blastocyst with morphological grade of 4BC/4CB and above on the 5th or 6th day (D5/6) after egg collection.
Exclusion criteria
Exclusion criteria: 1. People with low response to the number of oocytes retrieved 3cm; 4. Congenital uterine abnormalities (such as unicornuate uterus, septate uterus, or double uterus); 5. One or both spouses have abnormal karyotypes; 6. Repeated spontaneous abortion: 2 or more consecutive occurrences of fetal loss before 28 weeks of gestation, including consecutive biochemical pregnancy; 7. Untreated severe endocrine disease; 8. Severe male factor infertility: including severe oligospermia (sperm concentration < 5 x 10^6/ml), azoospermia, severe teratospermia (sperm deformity rate 100%), asthenozoospermia (forward motile sperm) rate 0%).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live Birth Rate of the first embryo transfer; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Pregnancy Rate of the first embryo transfer;Continuous Pregnancy Rate;Miscarriage rate;Ectopic pregnancy rate;Cumulative Live Birth Rate during one cycle of egg retrieval;Time to live birth; | — |
Countries
China
Contacts
Public ContactYe Hong
Chongqing Maternal and Child Health Hospital
Outcome results
None listed