Degenerative diseases of the bone and joint
Conditions
Interventions
Experimental group 1:Rongjian Rejuvenation Granules
Control group 1 :Paracetamol
Experimental group 2:Routine treatment+Radix AngelicaeSinensis Blood Tonic Soup
Control group 2:Routine treatment
Sponsors
Gansu Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Research plan one: 1. Meet the diagnostic criteria of the "Guidelines for the Diagnosis and Treatment of Osteoarthritis" issued by the Orthopaedic Branch of the Chinese Medical Association; 2. Patients with Kellgren-Laurance (K-L) radiological diagnosis grades I, II or III. (Grading criteria for KL: 0, completely normal; 1, suspected narrowing of the joint space, possible osteophytes; 2, obvious osteophytes, normal or suspected narrowing of the joint space; III, moderate osteophytes, joint space Clearly narrow space, partial sclerosis of subchondral bone; grade IV, huge osteophytes, markedly narrowed joint space, severe sclerosis of subchondral bone, clear deformity) 3. Aged 50 to 75 years; 4. Patients who have not received systematic treatment for knee osteoarthritis in the past 1 month, and can adhere to the treatment as planned, and can cooperate with clinical observers and follow-up; 5. Subjects are fully aware of the nature of this study, the nature of their disease, and can understand and sign the informed consent. Research plan two: 1. Meet the diagnostic criteria of research protocol 1; 2. All are primary unilateral total knee arthroplasty, and the estimated operation time is within 90 minutes; the blood loss is 500-1500ml (including postoperative occult bleeding); 3. Preoperative examination of liver and kidney function and coagulation function is normal; 4. There was no obvious abnormality in preoperative color Doppler ultrasonography of lower extremity blood vessels; 5. No recent active infection; 6. No previous history of related coagulation disorders and vascular embolism; 7. No neuromuscular dysfunction; 8. No history of osteomyelitis in the affected limb, no serious peripheral vascular disease; 9. No serious systemic coexisting diseases, able to tolerate surgery and voluntarily participate in the research of this project, and sign the informed consent.
Exclusion criteria
Exclusion criteria: Research plan one: 1. Those who have undergone joint surgery on the affected knee in the past; 2. Pregnant and lactating women; 3. In patients with liver function tests whose detection values ??of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are higher than 120% of the upper limit of normal, renal function tests for blood urea nitrogen (Bun) and creatinine (Cr) exceed the upper limit of normal. Diabetic patients requiring insulin injection or poor blood sugar control with oral drugs (fasting blood sugar >= 10 mmol/L). Multiple abnormalities of coagulation function, abnormal blood routine (neutrophils, white blood cells, red blood cells, platelets, hemoglobin, monocytes); 4. Other diseases affecting the knee joint, such as psoriasis, syphilitic neuropathy, Charcot's joint disease, brown yellow disease, metabolic bone disease, acute trauma, etc.; combined with cardiovascular, cerebrovascular, liver, kidney, hematopoietic Patients with serious primary diseases such as the system, endocrine system, digestive system and mental illness; patients with secondary or traumatic knee osteoarthritis; patients with colds or infectious diseases in the past month; 5. Those with a history of opioid analgesics, sedative-hypnotics and alcohol abuse, or those with contraindications to treatment, or those with a history of allergies to the drugs used in the study; 6. Those who are participating in other clinical trials that affect the evaluation of the results of this study; 7. Those who have undergone intra-articular drug injection within the past 6 months; those who are ready to undergo total knee replacement within the past year; those who have used Chinese or Western medicines with analgesic and analgesic effects within the past 1 month or who have systematically received knee osteoarthritis Patient; 8. Those who cannot walk independently and need to rely on assistive devices such as canes to walk; those who cannot cooperate with assessment, treatment and testing for other reasons. Research plan two: Nil.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of the efficacy of Chinese medicine Radix Angelicae Sinensis Blood Tonic Soup;Laboratory test indicators: detection of red blood cell count (RBC), detection of hemoglobin (HGB), red blood cell specific volume (HCT), platelet count (PLT), platelet specific volume (PCT), mean platelet volume (MPV), anemia triad (serum ferritin concentration, vitamin B12, folic acid); | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS pain score;WOMAC Knee Score;Knee Function Outcome Survey - Daily Living Abilities Scale;Timed stand-up-walk test;6 minutes walking test; | — |
Countries
China
Contacts
Public ContactLi Shenghua
Gansu Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed