knee osteoarthritis
Conditions
Interventions
HA:2.5ml HA+3ml saline each week for 4 consecutive weeks.
PRP:3ml PRP+ 2.5ml saline each week for 4 consecutive weeks.
Combination (PRP+HA):PRP 3ml+ HA 2.5ml each week for 4 consecutive weeks.
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: aged 50 to 80 years; diagnosed as knee osteoarthritis for at least 6 months according to American College of Rheumatology (ACR) criteria involving radiography results[18]; with pain of at least 40 mm on a 100-mm visual analog scale (VAS) reported one month after conservative treatment of KOA recommended by guidelines (including nonpharmacological treatment, oral NSAID, or intra-articular injection of glucocorticoids); graded III and IV according to Kellgren-Lawrence radiological classification on X-ray image[5]; able to cooperate with knee ultrasound examination; able to listen, speak, read and write in Chinese; capable of understanding the study requirements and willing to cooperate with the study instructions; willing to sign an informed consent form.
Exclusion criteria
Exclusion criteria: accompanied by other inflammatory arthritis (such as gout, reactive arthritis, psoriatic arthritis, seronegative spinal arthritis, etc.), rheumatic or autoimmune diseases; previous or anticipated knee surgery in the next 1 year; severe genu valgus deformity (valgus angle > 30°) or previous trauma; intraarticular injection in the last 4 weeks; oral corticosteroid used in the last 2 weeks or NSAID used in the last 2 days; anticoagulant and antiplatelet drugs used in the last 10 days; hemoglobin < 10g/dL, platelet count < 150×109/L; history of infectious diseases such as HIV positive; recently suffered from febrile diseases; with hematopoietic or skeletal cancer; accompanied by coagulation dysfunction; pregnant or lactating women; unstable vital signs; unable to complete or withdraw from the treatment regimen.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change of WOMAC score at 6 months follow up compared with the score at baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| suprapatellar sac effusion;Grading of synovitis;Times up and go;SF-12;The change of WOMAC score at 1 and 3 months follow up compared with the score at baseline; | — |
Countries
China
Contacts
Public ContactJiang Li
The Sixth Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed