ANCA-associated glomerulonephritis
Conditions
Interventions
Experimental group:Rituximab therapy during induction of AAGN
Sponsors
Pediatric Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
2 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of granulomatosis with polyangiitis (GPA) (EULAR/PRINTO/PRES, 2008 classification criteria) and microscopic polyangiitis (MPA) (Chapel Hill consensus meeting, 2012) . 2. Aged 2-18 years, no gender limit. 3. Patients with newly diagnosed AAGN who meet the following definitions: (1) Evidence of kidney damage: 24-hour urine protein>0.3g/d, or urine protein/creatinine > 0.3, or microscopic red blood cells > 5/HP, or pathologically confirmed AAGN necrotizing pauci-immune complex glomerulonephritis; (2) Pediatric Vasculitis Activity Score (PVAS) in children is greater than or equal to 3 points, and the disease is severe enough to warrant the use of CYC; (3) Positive for PR3-ANCA or MPO-ANCA at screening. 4. Mandatory prophylactic treatment for Pneumocystis jirovecii infection is mandatory for all eligible participants. 5. The legal guardian of the subject fully knows and signs the informed consent, and the subject can cooperate to complete the follow-up.
Exclusion criteria
Exclusion criteria: 1. Patients requiring mechanical ventilation due to alveolar hemorrhage. 2. There is a history of anti-glomerular basement membrane disease (anti-GBM). 3. Active systemic infection. 4. Deep infection such as osteomyelitis, septic arthritis or pneumonia complicated by thoracic abscess or lung abscess within 6 months before entering the study. 5. Active infectious disease: history of HIV, syphilis, tuberculosis, hepatitis B or hepatitis C infection. 6. Acute or chronic liver disease. 7. Have any known malignancy, or a history of malignancy in any organ system within the past 5 years. 8. Other uncontrolled diseases. 9. Pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urine protein;kidney function;blood pressure;pediatric vasculitis activity score; | — |
Countries
China
Contacts
Public ContactSun Li
Pediatric Hospital Affiliated to Fudan University
Outcome results
None listed