burn
Conditions
Interventions
control group:saline 4ml was administered 20min before operation and immediately after operation
low dosage group:40mg parecoxib sodium was dissolved in 4ml saline and administered 20min before operation, and saline 4ml was administered immediately after operation
moderate dosage group:40mg parecoxib sodium was dissolved in 4ml saline and administered 20min before operation, and 20mg parecoxib sodium was dissolved in 4ml saline and administered immediately afte
high dosage group:40mg parecoxib sodium was dissolved in 4ml saline and administered 20min before operation and immediately after operation
Sponsors
Wuhan Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with moderate or severe burns; 2. Patients who are scheduled to undergo escharectomy and skin grafting; 3. Patients aged between 18-75 years; 4. Wwilling to participate in this researcher and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with cognitive dysfunction disease or preoperative MMSE lower than 27; 2. The patient has a history of allergy to non-steroidal anti-inflammatory drugs or developed peptic ulcer, bleeding and perforation after taking it; 3. Patients with severe hepatic or renal impairment; 4. Pregnant or lactating patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain degree;Serum levels of inflammatory factors;Cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Consciousness; | — |
Countries
China
Contacts
Public ContactHu Guangjun
Wuhan Third Hospital
Outcome results
None listed