Stroke
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. In line with the 2018 edition of the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke; 2. No obvious cognitive impairment (MMSE>=25 points); 3. The first onset was confirmed by head CT or MRI, and the disease course was stable within 2 weeks to 3 months; 4. Upper limb Brunnstrom stage II-V with unilateral upper limb hand movement dysfunction; 5. Aged 18-80 years, gender is not limited; 6. Informed about the research of this subject, read and signed informed consent by the patient himself or his immediate family.
Exclusion criteria
Exclusion criteria: 1. Severe spasticity (modified Ashworth spasticity scale > 2 points); 2. Obvious pain in the hemiplegic limb (VAS score > 4); 3. Obvious sensory dysfunction, aphasia, lateral neglect, apraxia or visual and hearing impairment; 4. Concurrent epilepsy or severe heart, liver, kidney and hematopoietic system and other important organ failure; 5. There are contraindications to TMS, including those with metal foreign bodies built into the skull, those with pacemakers, those with cardiac stents, those with cochlear implants, those with significantly increased intracranial pressure, etc.; 6. There is a history of alcohol or drug abuse; 7. Those who cannot complete the basic course of treatment and may have poor compliance; 8. Non-local patients who cannot be followed up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Upper Limb Motor Function Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Boxing and Blocking Test;Modified Ashworth Score;Montreal Cognitive Assessment Scale;Modified Barthel Index;TMS Assessment; | — |
Countries
China