A randomized controlled trial on the prevention and treatment of radiation dermatitis after head and neck tumor and breast cancer with Siemuron Contrast-vitamin E cream

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100050910

Enrollment

Unknown

Registered

2021-09-07

Start date

2021-09-15

Completion date

Unknown

Last updated

2022-05-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Radioactive dermatitis

Interventions

Experimental group:Skin lotion for radiating skin, 2 times/day

Control group:Vitamin E lotion for skin irradiation, 2 times/day

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with head and neck squamous cell carcinoma or breast cancer; 2. The total dose of skin irradiation >= 50Gy; 3. Aged 18-65 years; 4. ECOG physical status score: 0-2 points, KPS Karnofsky behavior status score> 70 points; 5. Sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Those who have received radiation therapy on the head, neck and chest before; 2. Those who have received laser or cryotherapy on the neck skin; 3. Those with high allergies and those who are allergic to test drugs; 4. Patients with local skin lesions combined with fungal infection; 5. Suffering from other diseases at the same time, such as uncontrolled infection, uncontrolled diabetes, etc.; 6. Communication barriers and non-cooperation.

Design outcomes

Primary

Measure	Time frame
The incidence of radioactive dermatitis II degrees or more;	—

Secondary

Measure	Time frame
(Skindex-16 QoL) Skin Index Questionnaire Score;	—

Countries

China

Contacts

Public ContactLong Xiaoli

Xijing Hospital

longxl@fmmu.edu.cn+86 13991833378

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 10, 2026