Thoracic disease
Conditions
Interventions
Group A:Conventional one-lung ventilation
Group B:Continuous positive airway pressure = 2 cmH2O, tidal volume = 40-60 mL
Group C:Continuous positive airway pressure = 5 cmH2O, tidal volume = 60-80 mL
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients aged 18-79 years scheduled for video-assisted thoracoscopic surgery (VATS) with one-lung ventilation for lobectomy under general anesthesia; 2. Agree to participate and sign the informed consent form; 3. ASA (American Society of Anesthesiologists) I-III; 4. Forced expiratory volume in 1 second (FEV1) >= 1.5 L; 5. Body mass index (BMI) 18-28 kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Desaturation below 85%; 2. Intraoperative conversion to thoracotomy; 3. Intraoperative pleural atresia or severe adhesions; 4. Previous history of pneumonectomy and cholecystectomy; 5. Patients with decompensated heart, lung, liver and kidney disease, abnormal coagulation function; 6. Pregnancy and difficult intubation; 7. Patients with severe respiratory diseases or malformations suggested by preoperative imaging data; 8. Patients with severe neuropsychiatric disorders, long-term alcohol, opioid or sedative-hypnotic drug addiction and dependence history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intrapulmonary shunt(Qs/Qt);PaO2;PaCO2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Field Satisfaction;Postoperative pulmonary complications; | — |
Countries
China
Contacts
Public ContactJia Ke
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed