Skip to content

Effect of cholinergic system on cognitive function of patients with mild hepatic encephalopathy and its imaging evaluation

Effect of cholinergic system on cognitive function of patients with mild hepatic encephalopathy and its imaging evaluation

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100050880
Enrollment
Unknown
Registered
2021-09-05
Start date
2021-09-10
Completion date
Unknown
Last updated
2022-05-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Minimal hepatic encephalopathy

Interventions

Control group:No
Mild hepatic encephalopathy group:No

Sponsors

General Hospital of Ningxia Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Patients with posthepatitic cirrhosis were diagnosed by clinical evaluation, laboratory examination and imaging examination; 2. Aged 30 to 60 years; 3. The education period is 6-12 years.

Exclusion criteria

Exclusion criteria: 1. Previous history of other neuropsychiatric diseases or psychotropic drug abuse; 2. According to the medical history and routine imaging examination, there is a medical history of brain parenchyma (brain tumor, stroke, brain trauma and brain metabolic diseases, etc.); 3. Previous history of alcoholism or alcoholic cirrhosis; 4. Suffering from diabetes, hypertension or other chronic metabolic diseases; 5. Unable to complete the scale evaluation of A(number connection test-A, NCT-A-a) and digital symbol test, DST) due to visual acuity, educational level and other reasons; 6. There are contraindications of MRI examination, such as metal implants in the body; 7. Excessive head movement during imaging examination (translation exceeds 1.0 mm or rotation exceeds 1.0 degree); 8. Previous drug-induced liver damage or alcoholic cirrhosis.

Design outcomes

Primary

MeasureTime frame
Cholinesterase;

Countries

China

Contacts

Public ContactWang Xiaodong

General Hospital of Ningxia Medical University

xdw80@yeah.net+86 13995199434

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026