Effect of antidepressant effect of esketamine on early postoperative delirium in patients undergoing cardiac valve replacement: a prospective, randomized, double-blind, parallel-controlled trial

Effect of Esketamine on postoperative neurocognitive function in patients undergoing cardiac surgery with cardiopulmonary bypass

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100050859

Enrollment

Unknown

Registered

2021-09-05

Start date

2022-08-30

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative delirium

Interventions

Control group:Normal saline

Experimental Group:Esketamine (0.25 mg/kg)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective heart valve replacement surgery; 2. Aged >= 18 years; 3. ASA II-III, NYHA II-III; 4. Voluntary consent to participate in the experiment; 5. Clearly understand and voluntarily agree to participate in the study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Have a history of neuropsychiatric diseases; personal history of mental retardation, language disorder; 2. Uncontrolled history of hypertension, diabetes, tumor, and blood diseases; 3. Have a long history of using psychoactive drugs or alcohol; 4. Insufficiency of lung, liver, and kidney function.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative delirium;	—

Secondary

Measure	Time frame
Vital signs change;Departure standard time;SDS score change;Duration of ICU;	—

Countries

China

Contacts

Public ContactShi Jing

The Affiliated Hospital of Guizhou Medical University

315585290@qq.com+86 18685034106

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026