Thoracic spinal fusion surgery
Conditions
Interventions
Intervention group:Intraoperative maintenance of deep muscle relaxation
Control group:Maintain moderate muscle relaxation during surgery
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-60 years; 2. ASA <= III; 3. Plan to undergo thoracic fusion under general anesthesia and the expected operation time is 2 hours or more; 4. Agree to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Abnormal renal function before operation (serum creatinine > 133 umol/ml); 2. Abnormal liver function (ALT or AST > 2 x ULN); 3. Combined neuromuscular disease or peripheral neuropathy, such as muscular dystrophy diseases, Guillain-Barre syndrome, diabetic peripheral neuropathy, etc.; 4. Acute and chronic respiratory diseases such as lung infection, asthma, bronchiectasis, within 2 weeks before surgery; 5. Body mass index BMI > 28 kg/m^2 or combined sleep apnea syndrome; 6. Pregnant women; 7. Allergic to the drugs involved in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative driving pressure level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of achieving deep muscle relaxation after the first induction dose;Intraoperative respiratory mechanics parameter level;The incidence of pulmonary complications within 30 days after surgery;Length of hospital stay after surgery ;Intraoperative oxygenation index;The area under the curve of the driving pressure during the operation; | — |
Countries
China
Contacts
Public ContactLi Yawei
Peking University First Hospital
Outcome results
None listed