Breast cancer
Conditions
Interventions
Lidocaine and Dexamethasone group:Injection of lidocaine 1.5mg/kg and dexamethasone 8mg (2ml)
Dexamethasone group:Injection of 0.9%NaCl (equal to lidocaine 1.5mg/kg) and dexamethasone 8mg (2ml)
Lidocaine group:Injection of lidocaine 1.5mg/kg and 0.9%NaCl (2ml)
Sodium chloride group:Injection of 0.9%NaCl (equal to lidocaine 1.5mg/kg) and 0.9%NaCl (2ml)
Sponsors
Cancer Hospital of Shantou University Medical College
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Female patients underwent elective unilateral total mastectomy under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. History of local anaesthetic or glucocorticoid allergy; 2. Simultaneous bilateral surgery, breast-conserving surgery, daily/current use of glucocorticoids or immunosuppressant drugs; 3. Cardiac insufficiency; 4. Severe arrhythmia; 5. Insulin-dependent diabetes mellitus; 6. Severe liver and kidney dysfunction; 7. History of chronic pain.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS scores after operation;Intraoperative opioid dosage;The dosage and frequency of opiates and other analgesics after operation;Incidence and severity of PONV(post-operative nausea and vomiting); | — |
Secondary
| Measure | Time frame |
|---|---|
| The occurrence and daily functional status of resting pain and motor pain in the morning and evening ;Tracheal extubation time (time from drug withdrawal to tracheal tube removal);Monitor the stay time in the treatment room after anesthesia;The situation in PACU after operation; | — |
Countries
China
Contacts
Public ContactXu Xiang
Cancer Hospital of Shantou University Medical College
Outcome results
None listed