Obstructive sleep apnea syndrome
Conditions
Interventions
Best supportive treatment group:Carry out the best supportive treatment
Best supportive treatment group and Vitamin B2(10 mg) group:Carry out the best supportive treatment and take vitamin B2(10 mg) three times a day
Best supportive treatment group and Vitamin B2(20 mg) group:Carry out the best supportive treatment and take vitamin B2(20 mg) three times a day
Sponsors
The Sixth People's Hospital Affiliated to Shanghai Jiaotong University
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. People with normal renal function aged 20-70 years: serum urea 2.5-6.4 mmol/L; blood creatinine 53-115 umol/L; uric acid 210-430 umol/L; 2. Sleep snoring more than 5 days a week, and apnea repeatedly occur or open mouth to breathe during sleep; 3. OSA patients with Friedman tonsils 0-1 degree diagnosed by laboratory standard polysomnography; 4. Participate in this clinical study voluntarily, sign an informed consent form, and be able to cooperate and complete the follow-up.
Exclusion criteria
Exclusion criteria: 1. Pregnant women or women who are breastfeeding; 2. Those who are allergic to vitamin B2; 3. Currently undergoing other treatments related to OSA; 4. Cardio-cerebrovascular diseases (heart failure, recurrent atrial fibrillation and stroke); respiratory diseases (respiratory failure, COPD); neurological diseases (epilepsy); advanced cancer and chronic inflammatory diseases; 5. Depression, mania, schizophrenia and other mental illnesses; 6. Those who are currently drinking regularly; 7. Currently using phenothiazines, tricyclic antidepressants, probenecid, metoclopramide (metoclopramide) and other drugs; or are using psychotropic drugs, sedatives, narcotics and other drugs; or using those with health products such as multivitamins that may have an impact on the research results; 8. Other sleep diseases: narcolepsy, insomnia, chronic sleep deprivation, REM behavior disorder and restless legs syndrome, central OSA or obesity hypopnea syndrome; 9. Have specified diseases or conditions excluded from research (physical or psychological, physical examination findings); 10. Participated in other clinical studies within 3 months before the start of the study or the investigator believes that there is any reason for not being suitable for participating in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective treatment (AHI index); | — |
Secondary
| Measure | Time frame |
|---|---|
| Compliance;Epworth Sleepiness Score and Quality of life score; | — |
Countries
China
Contacts
Public ContactYin Shankai
The Sixth People's Hospital Affiliated to Shanghai Jiaotong University
Outcome results
None listed