Pediatric anesthesia
Conditions
Interventions
Control group:Not receiving any sedative drugs
Midazolam group:Midazolam 0.1mg/kg
Low-dose esketamine group:Low-dose esketamine 0.3mg/kg
Medium-dose esketamine group:Medium-dose esketamine 0.5mg/kg
High-dose esketamine group:High-dose esketamine 0.7mg/kg
Sponsors
He'nan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. Aged 1-6 years; 2. ASA classification I-II; 3. Elective non-cardiac surgery under general anesthesia; 4. Parents voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Unconsciousness; 2. Nervous system diseases; 3. Received sedation treatment 72 hours before surgery; 4. Intellectual deficiency; 5. Failure to open venous access before surgery; 6. Needle phobia; 7. Neurosurgery; 8. EEG detection cannot be achieved in maxillofacial surgery; 9. Liver insufficiency; 10. Participated in other clinical trials within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety score;Motor assessment scale (MAS);Mean arterial pressure;Heart rate;SpO2;Face, legs, activity, cry and consolability pain scale (FLACC score);Resuscitation assessment;Adverse reactions;Electroencephalogram (EEG); | — |
Countries
China
Contacts
Public ContactYang Yitian
He'nan Provincial People's Hospital
Outcome results
None listed