lung cancer
Conditions
Interventions
Control group:Intravenous pumping 0.9%NS
Lidocaine group:Intravenous pumping lidocaine
Dexmedetomidine group:Intravenous pumping dexmedetomidine
Lidocaine combined with dexmedetomidine group:Intravenous pumping lidocaine and dexmedetomidine
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years; 2. Patients undergoing elective thoracoscopic resection of lung cancer; 3. Normal liver and kidney function; 4. The ASA classification is I to III; 5. Patients with lung cancer without distant dissemination (clinical stage <=II); 6. Consent to receive postoperative controlled analgesia and intraoperative intercostal nerve block; 7. Willing to accept long-term follow-up.
Exclusion criteria
Exclusion criteria: 1. Preoperative neoadjuvant chemotherapy or radiotherapy; 2. Pregnant women; 3. Allergic to lidocaine, ropivacaine, sufentanil, rocuronium and other anesthetic drugs; 4. Previous long-term treatment with beta-blockers; 5. There was preoperative coagulation dysfunction; 6. Preoperative severe heart disease (NYHA cardiac function grade >= III); 7. Severe renal insufficiency (serum creatinine > 118mg/dL) or renal replacement therapy; 8. Severe liver insufficiency (modified Child-Pugh grade C); 9. Preoperative acute infection is not well controlled; 10. Poor preoperative glycemic control (FBP over 3.9-13.8mmol/L); 11. Opioid abuse; 12. Mental health problems or cognitive impairment; 13. Patients with a history of epilepsy and taking medication; 14. Chronic inflammatory or autoimmune disease or previous long-term use of glucocorticoids or other inflammatory immunosuppressive therapy; 15. Patients with other anesthesia or surgery contraindications; 16. The patient refused to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myeloperoxidase (MPO), a specific index of neutrophils extracellular trapping net in serum ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Citrullinated histone (H3Cit), a specific index of neutrophils extracellular trapping net in serum;Tumor progression and metastasis related markers (VEGF-A, MMP-3, MMP-9) in serum;VAS scores at 24, 48, and 72 hours after operation at rest or on movement ;Qor-40 scores at 1, 2, and 3 days after surgery;Additional analgesic timepoint and opioid use were required for the first time after surgery;Gastrointestinal first exhaust, defecation time;Postoperative drainage tube removal time;All-cause mortality 30 days after surgery;Readmission rate due to complications 30 days after surgery;Length of stay; | — |
Countries
China
Contacts
Public ContactWang Zhiping
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed