periprosthetic joint infection
Conditions
Interventions
Systemic use of antiboitics group:Systemic antimicrobial therapy for periprosthetic infections
Systemic use combined with intra-articular local application of antibiotics group:Treatment of periprosthetic infections with systemic systemic combined with local intra-articular antibiotics
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of PJI: there is a sinus tract that communicates with the prosthesis; or the same pathogen is isolated from 2 periprosthetic tissues or synovial fluid specimens of the affected artificial joint; or 4 of the following 6 are satisfied: (1) Elevated erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) level; (2) Increased synovial leukocyte count; (3) The percentage of synovial neutrophils (PMN) increased; (4) suppuration in the affected joints; (5) Microorganisms were isolated from periprosthetic tissue or synovial fluid specimens in one culture; (6) At 400x magnification, the pathological analysis of the tissue around the prosthesis found >5 centrioles in 5 high-power fields. If less than 4 of the criteria are met, periprosthetic joint infection may exist; 2. Hospitalized patients who underwent revision surgery for periprosthetic infection after joint replacement since October 1, 2021; 3. Case data can be checked.
Exclusion criteria
Exclusion criteria: 1. Patients without periprosthetic infection treatment after joint replacement in our department; 2. Those who did not sign informed consent during the perioperative period; 3. Patients who were lost to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood routin;erythrocyte sedimentation rate;C-reaction protein;interleukin 6;D-dimer;Synovial fluid polynuclear cell count;Synovial fluid polynuclear cell percentage;the concentration of antibiotics; | — |
Countries
China
Contacts
Public ContactHuang Wei
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed