perimenopausal syndrome
Conditions
Sponsors
Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Healthy women aged 40-65 years; 2. Menstrual disorders persist for more than 3 months, or amenorrhea within 2 to 12 months; 3. Suffering from any of the following symptoms: vasomotor symptoms (hot flashes, sweating), somatic symptoms (insomnia, fatigue, headache, paresthesia), psychological symptoms (nervousness, depression) or genitourinary symptoms (dyspareunia) , vaginal dryness, urinary tract infection); 4. Serum follicle stimulating hormone (FSH) > 10 IU/L, or decreased estradiol (E2) 5. Have not received hormone replacement therapy or other drugs for perimenopausal symptoms in the past 2 months; 6. The uterus and bilateral appendages are intact without resection; 7. Sober and patients accept informed consent.
Exclusion criteria
Exclusion criteria: 1. Ovarian malignant tumor, premature ovarian failure, uterine fibroids >= 2cm, severe breast hyperplasia; 2. Combined with gynecological acute infectious diseases or other acute infectious diseases; 3. Severe liver and kidney dysfunction or other serious systemic diseases; 4. Participated in other clinical trials; 5. Patients who did not receive treatment as prescribed or who dropped out of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The modified Kupperman Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hot flash scale (HFs);Menopause-Specific Quality of Life (MENQOL) Scale;Hamilton Depression(HAMD)Scale;Hamilton Anxiety Scale(HAMA) Scale;Sex hormone;Monoamine neurotransmitter;Vascular vasomotor factor;Expression of serum protein and mRNA level of phosphatidylinositol 3-active enzyme (PI3K), protein activator enzyme B(Akt), and phosphorylated protein kinase B(pAkt); | — |
Countries
China
Contacts
Public ContactXu Xiaohu
Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
Outcome results
None listed